Take the A2 highway exit for Luzern-Horw. You will find various parking options at the exhibition site. A parking fee is charged.
By public transport
Take the S-Bahn (Metro) that leaves Lucerne main station every 15 minutes (at 12, 27, 42 and 57 minutes past the hour) and get off 2 minutes later at the station named Allmend/Messe. Alternatively, bus line 20 will bring you to the Swiss Medtech Expo from Lucerne main station in just 8 minutes.
Accommodation in Lucerne
Here you can find accommodation close to the fair. Lucerne Tourism is giving away a free public transport ticket for every overnight stay at a hotel.